DNA sequencing using nanopores and kinetic proofreading

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We discuss the feasibility of using a nanopore sandwich device to implement the principle of kinetic proofreading to discriminate incorrect hybridizing oligonucleotides on a target DNA or RNA.We propose a method of sequencing DNA or RNA using this approach.The design parameters for such a DNA sequencer are estimated from the HopfieldNinio theory of kinetic proofreading and Schr(o)dinger’s first-passage-time distribution function.
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