【摘 要】
：
Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat,ultraviolet radiation,water loss,and mechanical forces.Here,using a comparative genomics analysis of 39 mammal species spanning three skin covering t
【机 构】
：
Key Laboratory of Drug Targets and Drug Leads for Degenerative Diseases,Affiliated Hospital of Integ
论文部分内容阅读
Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat,ultraviolet radiation,water loss,and mechanical forces.Here,using a comparative genomics analysis of 39 mammal species spanning three skin covering types(hairless,scaly and spiny),we found some genes(e.g.,UVRAG,POLH,and XPC)involved in skin inflammation,skin innate immunity,and ultraviolet radiation damage repair were under selection in hairless ocean mammals(e.g.,whales and manatees).These signatures might be associated with a high risk of skin diseases from pathogens and ultraviolet radiation.Moreover,the genomes from three spiny mammal species shared convergent genomic regions(EPHB2,EPHA4,and NIN)and unique positively selected genes(FZD6,INVS,and CDC42)involved in skin cell polarity,which might be related to the development of spines.In scaly mammals,the shared convergent genomic regions(e.g.,FREM2)were associated with the integrity of the skin epithelium and epidermal adhesion.This study identifies potential convergent genomic features among distantly related mammals with the same skin covering type.
其他文献
The brown planthopper (BPH) (Nilaparvata lugens St(a)l) is a highly destructive pest that seriously damages rice (Oryza sativa L.)and causes severe yield losses.To better understand the physiological and metabolic mechanisms through which BPHs respond to
Male sterility is an essential trait in hybrid seed production,especially for monoclinous and autogamous food crops.Soybean male-sterile ms1 mutant has been known for more than 50 years and could be instrumental in making hybrid seeds.However,the gene res
Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in
According to an annual flagship report produced jointly by the FAO and several other organizations,almost 690 million people,or 8.9 percent of the world\'s population,were still suffering from chronic hunger in 2019 (FAO et al.,2020).Moreover,the disast
Commensal bacteria boost serum IgG production in response to oral immunization with antigen and cholera toxin(CT)in a manner that depends on Nod2(nucleotide-binding oligomerization domain-containing protein 2).In this study,we examined the role of intesti
Epidermal growth factor(EGF)has been shown to improve piglet intestinal morphology and epithelial recovery.In an attempt to further understand the mechanisms behind these improvements,this study tested the hypothesis that dietary EGF may affect intestinal
Dear Editor,rnLung disease is a serious concern in humans and domestic animals.Huge economic losses are caused by enzootic pneumonia in the swine industry worldwide (Maes et al.,2018).The lung can be easily invaded by environmental pathogens,resulting in
Subcutaneous fat(SCF)and intramuscular fat(IMF)deposition is relevant to health in humans,as well as meat production and quality in pigs.In this study,we generated RNA sequence data for 122 SCF,120 IMF,and 87 longissimus dorsi muscle(LDM)samples using 155
RtcB,a highly conserved RNA ligase,is found in all three domains of life,and demonstrated to be an essential tRNA splicing component in archaea and metazoans.However,the biological functions of RtcB in bacteria,where there is no splicing,remains to be cla
Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their fun