发病机理本世纪70年代,对抗生素相关性胃肠道损害,已经有进一步的新认识。开初,伪膜性肠(结肠)炎(Pseudomembranous entero-colitis)认为是手术后的一种并发症。然而,重金属中毒、缺血性心脏病、尿毒症,以及肠梗阻等各种疾患,也均曾被认为是其相关因素。因而曾有过较多的命名,诸如手术后肠炎、坏死性结肠炎、缺血性结肠炎、尿毒症性结肠炎等。在过去的30年中,抗生素疗法成了最主要的危险因素。最初的病理发现, Pathogenesis 1970s, antibiotic-related gastrointestinal damage, there have been further new understanding. Initially, pseudomembranous entero-colitis was considered a complication after surgery. However, various diseases such as heavy metal poisoning, ischemic heart disease, uremia and intestinal obstruction have all been considered as related factors. Therefore, there have been more names, such as postoperative enteritis, necrotizing colitis, ischemic colitis, uremic colitis and so on. Antibiotic therapy has become the leading risk factor for the past 30 years. The initial pathological findings,