大蒜素(allicin)又名大蒜新素,为百合科葱属草本植物大蒜的鳞茎提取物,现可人工合成,化学名称为二烯丙基三硫化物。以往研究认为,大蒜素具有抗真菌、抗肿瘤、抗血小板聚集、降血脂及Ca~(2+)拮抗等作用。近年来,发现大蒜素对缺血性心脑血管疾病及缺血-再灌注损伤具有重要作用。现将大蒜素对心肌缺血-再灌注损伤的保护作用及其可能机制综述如下。 Allicin, also known as garnetin, is a bulb extract of Allium, a herb belonging to the genus Allium. It can be synthesized artificially and its chemical name is diallyl trisulfide. Previous studies have suggested that allicin has antifungal, anti-tumor, anti-platelet aggregation, hypolipidemic and Ca~(2+) antagonistic effects. In recent years, it has been found that allicin has an important role in ischemic cardiovascular and cerebrovascular diseases and ischemia-reperfusion injury. The protective effect of allicin on myocardial ischemia-reperfusion injury and its possible mechanisms are summarized below.