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目的:评价乌司他丁与奥曲肽联用对急性胰腺炎(AP)患者体征恢复及其对血液流变学的影响。方法:选取2010年7月—2015年8月间收治的AP患者108例,采用随机数字表法将其分为观察组和对照组,每组54例;对照组患者给予奥曲肽治疗,观察组患者在对照组基础上加用乌司他丁治疗;比较两组患者治疗后的总有效率及体征复常时间,以及治疗前后全血比高切黏度、血浆比黏度、血小板黏附率等血液流变学指标的变化。结果:观察组患者治疗后腹痛、腹膜刺激征、腹胀、恶心呕吐等体征症状复常时间快于对照组(P<0.05);治疗后观察组患者全血比高切黏度、血浆比黏度、血小板黏附率测得值低于对照组(P<0.05)。结论:采用乌司他丁与奥曲肽联用治疗AP患者疗效显著,改善了其血液流变学各指标,体征症状复常时间快于单用奥曲肽的治疗。
Objective: To evaluate the effect of ulinastatin combined with octreotide on the recovery of signs in patients with acute pancreatitis (AP) and its effect on hemorheology. Methods: One hundred and eighty patients with AP who were admitted between July 2010 and August 2015 were randomly divided into observation group and control group, with 54 cases in each group. Patients in the control group were treated with octreotide, and in the observation group In the control group based on the use of ulinastatin treatment; comparison of the two groups of patients after treatment, the total effective rate and recovery time, and before and after the whole blood than high shear viscosity, plasma viscosity, platelet adhesion rate and other blood rheology Changes in learning indicators. Results: After treatment, abdominal pain, peritoneal irritation, abdominal distension, nausea and vomiting were more frequent in the observation group than those in the control group (P <0.05). After treatment, the whole blood of the observation group was higher than the high shear viscosity, plasma specific viscosity, Adhesion rate was lower than the control group (P <0.05). Conclusion: The combination of ulinastatin and octreotide is effective in the treatment of patients with AP, and the indexes of hemorheology are improved, and the signs and symptoms of recurrent anorexia are faster than that of octreotide alone.