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应用核酸杂交（ｄｏｔｂｌｏｔ）分析５０例胃癌及其对应正常组织ｃ－ｍｙｃ癌基因扩增情况。结果１１例（２２％）存在２－６倍扩增，并发现扩增与胃癌的分化程度、临床分期明显相关。本研究表明，ｃ－ｍｙｃ癌基因激活在胃癌属较晚期事件，可能涉及部分胃癌的某些恶性行为，ｃ－ｍｙｃ扩增可能是一项判断胃癌预后的有用的分子标志。
The nucleic acid hybridization (dotblot) was used to analyze the amplification of c-myc oncogene in 50 cases of gastric cancer and its corresponding normal tissues. Results There were 2-6 fold amplifications in 11 patients (22%). It was found that the amplification was significantly related to the degree of differentiation and clinical stage of gastric cancer. This study shows that c-myc oncogene activation is a relatively late event in gastric cancer and may involve some malignant behaviors of some gastric cancers. C-myc amplification may be a useful molecular marker for judging the prognosis of gastric cancer.