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目的观察牛黄熄风胶囊对大鼠脑内囊出血的疗效，并初步探讨其作用机理。方法脑出血动物随机分为牛黄熄风胶囊组、脑血康组和盐水对照组，分别以牛黄熄风胶囊、脑血康和生理盐水灌胃治疗７ｄ，在治疗前后检查神经功能和病理学改变。结果①除盐水对照组外，牛黄熄风胶囊和脑血康组动物治疗后的神经病学评分均低于治疗前和盐水对照组（Ｐ＜０．０１）；但两药物治疗组无显著性差异（Ｐ＞０．０５）。②脑组织切片的病理检查发现，牛黄熄风胶囊治疗后，脑血肿缩小，吞噬细胞数量及活性增加，局部脑水肿消失，其病理学恢复均优于脑血康治疗组；盐水对照组仅见少量巨噬细胞浸润，其病变明显重于两药物治疗组。结论牛黄熄风胶囊可促进脑出血动物的形态及神经功能的恢复，其作用优于脑血康。
Objective To observe the curative effect of Niuhuang Xifeng Capsule on intracerebral hemorrhage in rats and to explore its mechanism. Methods Intracerebral hemorrhage was randomly divided into two groups: Bezoar Xifeng capsule group, Naoxuekang group and saline control group. The animals were treated with bezoar Xifeng capsule, Naoxuekang and saline for 7 days respectively. The neurological function and pathological changes were observed before and after treatment . Results ① Neurological scores of the animals treated with Niuhuang Xifeng Capsule and Naoxuekang were lower than those of the control group before and after salinization (P <0.01) except for the saline control group, but there was no significant difference between the two drug treatment groups (P> 0.05). ② Pathological examination of brain tissue sections revealed that after the treatment with bezoar Xifeng capsule, the brain hematoma decreased, the number and activity of phagocytic cells increased, and local brain edema disappeared, and the pathological recovery was better than that of Naoxuankang; only a small amount of saline control group was seen Macrophage infiltration, the lesions significantly heavier than the two drug treatment group. Conclusion Niuhuang Xifeng Capsule can promote the morphological and neurological recovery of intracerebral hemorrhage and its effect is superior to Naoxikang.