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经鼓膜穿刺中耳腔内注射4%利多卡因可以改善耳鸣和眩晕,但确切的作用机理尚不清楚。阪田等(1984)推测利多卡因可以阻断内耳毛细胞异常兴奋的恶性循环。本文研究旨在通过扫描电镜观察中耳腔内注射利多卡因后内耳的形态学改变以探讨其治疗耳鸣和眩晕的机理。实验动物采用鸽子和豚鼠。4%和10%利多卡因0.1m经鼓膜穿刺注入中耳腔,1～4天后分别取鸽子前庭器官和豚鼠耳蜗进行扫描电镜观察。注射4%利多卡因后不久豚鼠鼓膜充血,头向注射耳一侧偏斜;5分钟后出现轻度眼震,可持续2～3小时。4%利多卡因注入中耳腔后一
The tympanic membrane in the middle ear injection of 4% lidocaine can improve tinnitus and vertigo, but the exact mechanism of action is not yet clear. Sakata et al. (1984) speculated that lidocaine could block the vicious circle of abnormal excitability of hair cells in the inner ear. The purpose of this study is to observe the morphological changes of the inner ear after middle lid injection of lidocaine by scanning electron microscopy to explore its mechanism of treating tinnitus and dizziness. Experimental animals using pigeons and guinea pigs. 4% and 10% lidocaine 0.1m was injected into the middle ear cavity through the tympanic membrane. The pigeon vestibular organs and guinea pig cochlea were observed after 1 ~ 4 days. Shortly after injection of 4% lidocaine, guinea pig’s tympanic membrane is hyperemic and deflects towards the side of the ear to which it is injected. Mild nystagmus occurs after 5 minutes and lasts for 2 to 3 hours. 4% lidocaine into the middle ear cavity after a