目的　观察阴茎海绵体自行注射前列腺素 E1 治疗糖尿病性阳萎的疗效。方法　对 30例合并有勃起功能障碍的糖尿病病人 ,在医生指导下施行自行阴茎海绵体内注射前列腺素 E1 。结果　病人勃起所需适宜剂量为 :15 μg2例 ,2 0μg 2 2例 ,2 5μg 1例 ,30μg 2例 ,40μg 1例 ,2例注射 40μg无有效勃起。勃起持续时间为 2 4～ 10 6分钟 (5 0 .7± 19.5分钟 )。不良反应有局部轻度疼痛和不适 6例 ,局部少量出血 3例 ,未发生阴茎长时间持续勃起。结论　阴茎海绵体内自行前列腺素 E1 注射是一项有效的治疗糖尿病性勃起功能障碍的可供选择的治疗方法。 Objective To observe the efficacy of penis injection of prostaglandin E1 in the treatment of diabetic impotence. Methods Thirty patients with diabetes mellitus with erectile dysfunction were injected with prostaglandin E1 under the guidance of doctors. Results The suitable doses for erectile patients were 2 cases of 15 μg, 2 0 cases of 2 cases, 2 cases of 25 μg, 2 cases of 30 μg and 1 case of 40 μg, while 2 cases of injection of 40 μg had no effective erection. The duration of erection was 24 to 106 minutes (50.7 ± 19.5 minutes). Adverse reactions were local mild pain and discomfort in 6 cases, 3 cases of local small amount of bleeding, penile sustained erection did not occur for a long time. Conclusion Injection of prostaglandin E1 into the penis is an effective treatment for diabetic erectile dysfunction.