众所周知,抗独特型抗体可作为免疫原诱导机体产生保护性免疫,且诱导产生的抗体具有与原始抗体相同或者类似的独特型,但不能和抗原结合。作者以仙台病毒HN分子特异的单克隆抗体A、B作为工具,成功地诱导出单克隆和多克隆抗独特型抗体。并且以此免疫动物,制备出较高滴度的能结合仙台病毒的抗仙台病毒抗体。以DE52纯化的抗仙台病毒单克隆抗体分别免疫同系的Lou鼠,同种源的BN、 It is well-known that anti-idiotypic antibodies can be used as immunogen to induce the body to produce protective immunity, and the induced antibodies have the same or similar idiotype as the original antibody but can not bind to the antigen. The authors have successfully induced monoclonal and polyclonal anti-idiotypic antibodies using Monoclonal antibodies A and B specific for Sendai virus HN. And the animals were immunized to prepare higher titer anti-Sendai virus antibodies that bind to Sendai virus. DE52 purified anti-Sendai virus monoclonal antibody were immunized with homologous Lou rats, allogenic BN,