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目的:探讨血清超敏C反应蛋白(hs-CRP)及红细胞分布宽度(RDW)与急性冠脉综合征(ACS)患者危险分层及预后的相关性。方法:将132例ACS患者按照全球急性冠状动脉事件注册(GRACE)危险评分分为低、中、高危三组;检测各组的血清hs-CRP、RDW、肌钙蛋白I(c Tn I)、B型脑钠肽(BNP)水平;并记录入院后心脏超声检查中左室射血分数(LEVF)及住院期间有无发生主要不良心脏时间(MACE)等情况。结果:低、中、高危三组间血清hs-CRP、RDW、BNP、c Tn I、LEVF比较具有统计学差异(P<0.05),高危组患者血清hs-CRP、RDW、BNP、c Tn I高于低危组及中危组(P<0.05),中危组高于低危组(P<0.05);血清hs-CRP水平与GRACE评分呈正相关(rs=0.490,P<0.05),RDW水平与GRACE评分亦呈正相关(rs=0.401,P<0.05);与非MECE组比较,MECE组患者hs-CRP、RDW较高(P<0.05);血清高水平hs-CRP及RDW是ACS患者发生近期住院MACE相关高危因素。结论:血清hs-CRP及RDW水平随着ACS患者危险分层的增加而增加,高水平hs-CRP及RDW是近期发生MACE的高危因素,对临床评估ACS患者病情及预后具有重要价值。
Objective: To investigate the relationship between serum hs-CRP, RDW and risk stratification and prognosis in patients with acute coronary syndrome (ACS). Methods: Thirty-two ACS patients were divided into low, medium and high risk groups according to the Global Acute Coronary Events Registry (GRACE) risk score. The serum hs-CRP, RDW, cTnI, (BNP), and to record the left ventricular ejection fraction (LEVF) after admission and the presence or absence of major adverse cardiac time (MACE) during hospitalization. Results: The levels of hs-CRP, RDW, BNP, cTn I, LEVF in low, medium and high risk groups were significantly different (P <0.05) (P <0.05), while the intermediate risk group was higher than the low risk group (P <0.05). The serum hs-CRP level was positively correlated with the GRACE score (rs = 0.490, P <0.05) The levels of hs-CRP and RDW in MECE group were significantly higher than those in non-MECE group (rs = 0.401, P <0.05), while the levels of hs-CRP and RDW in serum were higher in ACS patients Recent hospitalization MACE related risk factors. CONCLUSIONS: Serum hs-CRP and RDW levels increase with the risk stratification of ACS patients. High levels of hs-CRP and RDW are risk factors for MACE in recent years and are of great value in the clinical evaluation of the disease and prognosis of patients with ACS.