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目的探讨鼻咽癌患者行普通放射治疗和调强放射治疗期间的心理状态及不良反应,为临床治疗提供依据。方法选取2012年1月至2013年6月间收治的106例进行放射治疗的鼻咽癌患者,按治疗方式不同分为试验组和对照组,试验组患者进行调强放射治疗,对照组患者进行普通放射治疗,比较两组患者在治疗期间的心理状态和不良反应发生情况。结果试验组患者不良心理状态发生率明显低于对照组;试验组急性不良反应(主要为黏膜反应、皮肤反应、口干、味觉改变和吞咽困难等)发生率明显高于对照组,但程度较轻,对照组患者以上反应较重。在晚期不良反应中,试验组患者黏膜、皮肤、口干、味觉改变和吞咽困难等不良反应发生率明显低于对照组,且多数为Ⅰ期,程度轻,但在视力损伤、听力下降等方面差异无统计学意义(P>0.05)。结论调强放射治疗可有效减轻患者负面心理,短期不良反应相对较轻,利于患者坚持治疗,可有效提高治疗成效,建议在临床上推广应用。
Objective To investigate the psychological status and adverse reactions of patients with nasopharyngeal carcinoma undergoing routine radiotherapy and intensity-modulated radiation therapy, and to provide the basis for clinical treatment. Methods A total of 106 patients with nasopharyngeal carcinoma treated by radiotherapy from January 2012 to June 2013 were divided into test group and control group according to different treatment methods. Patients in test group received intensity-modulated radiation therapy and patients in control group General radiotherapy, the two groups of patients during the treatment of psychological status and adverse reactions. Results The incidence of adverse psychological state in the experimental group was significantly lower than that in the control group. The incidence of acute adverse reactions (mainly mucosal reaction, skin reaction, dry mouth, taste changes and dysphagia) in the experimental group was significantly higher than that in the control group Light, the control group patients more serious reaction. In the late adverse reactions, the incidence of adverse reactions such as mucosa, skin, dry mouth, taste changes and dysphagia in the test group were significantly lower than those in the control group, and most of them were stage Ⅰ, but the degree was mild. However, in the visual impairment and hearing loss The difference was not statistically significant (P> 0.05). Conclusion IMRT can effectively reduce the negative psychology of patients, short-term adverse reactions are relatively mild, which will help patients adhere to the treatment, which can effectively improve the treatment effect, it is recommended to promote the clinical application.