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文献多认为在肝病时转化生长因子β1(TGFβ1)可通过刺激贮脂细胞,调控细胞外基质的合成,致使肝纤维化.本文采用了免疫组织化学染色技术着重观察了病毒性肝炎肝细胞内TGFβ1的表达,试图探讨其与细胞凋亡的关系.一、资料与方法1.材料:52例肝穿组织系1994～1996年北京佑安医院病理科收检标本,其中急性肝炎8例,慢性肝炎轻度19例,慢性肝炎中度20例,慢性肝炎重度5例.病理诊断按1995年第五次全国传染病与寄生虫学术会议(北京)修订的病理组织学诊断标准.52例中血清学乙型肝炎病毒标志阳性40例,丙型肝炎患者12例.4例正常对照取自非肝病尸检肝组织,每例肝组织经甲醛固定,石蜡包埋,5
The literature more that in the liver disease, transforming growth factor β1 (TGFβ1) by stimulating fat storage cells, regulating the synthesis of extracellular matrix, resulting in liver fibrosis.In this paper, the use of immunohistochemical staining technique to observe the viral hepatitis hepatocytes TGFβ1 In order to explore its relationship with apoptosis.Materials and Methods1.Material: 52 cases of liver wear tissue from 1994 to 1996 Beijing You’an Hospital pathology specimens, including 8 cases of acute hepatitis, chronic hepatitis Mild in 19 cases, moderate in 20 cases of chronic hepatitis, severe hepatitis in 5. Pathological diagnosis according to the 1995 Fifth National Conference on Infectious Diseases and Parasitology (Beijing) revised histological diagnostic criteria.52 cases of serology Hepatitis B virus positive in 40 cases, hepatitis C in 12 cases .4 cases of normal controls were taken from non-liver disease autopsy liver tissue, each case of liver tissue fixed by formaldehyde, embedded in paraffin 5