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目的：改进安乃近片的含量测定方法。方法：（１）按２０００年版《中国药典》二部的含量测定方法，但将溶液过滤后再测定；（２）采用紫外分光光度法测定。结果：（１）法变色敏锐，终点非常明显，有效地消除了赋形剂的影响，平均回收率为 ９９．７６％，ＲＳＤ＝０．２８％（ｎ＝６）；（２）法测定波长为２５９ｎｍ时，浓度在１０－２５μｇ／ｍＬ范围内与吸收度呈良好线性关系（ｒ＝ ０．９９９ ９），平均回收率为 １００．１５％，ＲＳＤ＝０．５２％（ｎ＝６）。结论：两法均适用于安乃近片的含量测定。
OBJECTIVE: To improve the method for the determination of metoprolol. Methods: (1) According to 2000 edition of “Chinese Pharmacopoeia” two determination of content, but the solution was filtered and then measured; (2) Determination by UV spectrophotometry. Results: (1) The method was sensitive and the end point was very clear. The average recovery rate was 99.76% and the RSD was 0.28% (n = 6). (2) The method of determining the wavelength (R = 0.999 9), the average recovery was 100.15% and the RSD was 0.52% (n = 6) at 259nm with a linear range of 10-25μg / mL. Conclusion: Both methods are suitable for the determination of metoprolol.