目前,在早期发现由于接触镉所致肾小管功能损伤的检测方法中,尿中β_2-微球蛋白(β_2—M)的测定应用最广。然而,有报道当尿pH降至约5.5时尿中β_2-M可发生降解,从而影响测定的精确性。另据报道镉接触者尿中α_1-微球蛋白(α_1-M)和β_2-M之间有显著相关。本实验试图说明在检测镉接触所致肾小管功能紊乱方面,测定α_1-M是否比测定β_2-M更为有效。 Currently, urinary β_2-microglobulin (β_2-M) is the most widely used method for the detection of renal tubular damage due to exposure to cadmium. However, it has been reported that β_2-M in urine can degrade when the urine pH drops to about 5.5, thereby affecting the accuracy of the assay. It was also reported that urinary α-microglobulin (α_1-M) and β_2-M were significantly correlated with cadmium exposure. This experiment attempts to demonstrate whether the determination of α 1-M is more effective than measuring β 2-M in detecting renal tubular dysfunction induced by cadmium exposure.