丁酸类化合物是一种４碳的短链脂肪酸，困其毒性较低，是近年来研究较为广泛的一种新的γ－珠蛋白基固诱导剂，已在体外、动物实验以及临床研究中得到证实，但其作用机制仍不清楚。组蛋白的去乙酰化作用、转录因子及信号转导机制等可能参与了亡的诱导过程；给药方式对其诱导作用亦有影响；丁酸类化合物有希望成为一种较为理想的用于治疗γ－珠蛋白基因缺陷疾病儿童患者的首选药物。 Butyric acid compounds are a kind of 4-carbon short-chain fatty acids with low toxicity and are new γ-globin base inducer widely studied in recent years. They have been used in vitro, animal experiments and clinical studies Confirmed, but its mechanism of action is still unclear. Histone deacetylation, transcription factors and signal transduction mechanisms may participate in the process of death induction; mode of administration also has an effect on its induction; butyric acid compounds hope to become a more ideal for the treatment γ-globin gene deficiency disease in children preferred drug.