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采用连续原子转移自由基聚合途径制备了两亲性三嵌段聚合物聚乙二醇-聚甲基丙烯酸N,N-二甲氨基乙酯-聚甲基丙烯酸正丁酯(PEG-PDMAEMA-PBMA),利用核磁共振氢谱(1 H NMR)和凝胶渗透色谱(GPC)对聚合物结构及分子量进行了表征.动态光散射(DLS)和透射电镜(TEM)结果证实该聚合物的自组装行为具有pH敏感性.通过改变水溶液的pH值可以精确地调控聚合物的自组装行为,从而获得胶束、纳米球、大囊泡和小囊泡等多种自组装结构.这些自组装结构的形成与PDMAEMA链段的质子化程度和聚合物的亲疏水平衡有关.
The amphiphilic triblock polymer, polyethylene glycol-N, N-dimethylaminoethylmethacrylate-poly-n-butylmethacrylate (PEG-PDMAEMA-PBMA) was prepared by continuous atom transfer radical polymerization ), And the structure and molecular weight of the polymer were characterized by 1 H NMR and GPC.The results of dynamic light scattering (DLS) and transmission electron microscopy (TEM) confirmed that the polymer was self-assembled Behavior is pH-sensitive.The self-assembly behavior of polymers can be accurately controlled by changing the pH value of aqueous solution to obtain a variety of self-assembled structures such as micelles, nanospheres, large vesicles and small vesicles. The formation is related to the degree of protonation of the PDMAEMA segment and the hydrophilic-hydrophobic balance of the polymer.