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目的探讨1/5剂量长方案在卵巢反应不良患者体外受精-胚胎移植(IVF-ET)治疗周期控制性超排卵(COH)中的应用。方法选取30例2012年再次行IVF-ET治疗的卵巢反应不良患者,用1/5剂量长方案治疗,与患者既往周期资料比较。结果 1/5剂量长方案周期患者年龄、Gn启动量和总量、Gn天数、HCG日血清E2水平、≥14mm卵泡数、获卵数、可用胚胎数及优质胚胎数均高于既往周期;受精率、卵裂率及优质胚胎率呈增高趋势(分别为81.1%比78.7%,79.7%比72.3%,43.2%比34.0%),但差异无显著性。1/5剂量长方案周期患者出现卵巢囊肿概率较高(20%,6/30)。结论 1/5剂量长方案能改善卵巢反应不良患者的卵巢反应,可能改善卵子质量。
Objective To investigate the application of 1/5 dose long-term regimen in the treatment of controlled ovarian hyperstimulation (COH) in IVF-ET patients with poor ovarian response. Methods Thirty patients with ovarian failure who were treated with IVF-ET again in 2012 were enrolled in this study. The patients were treated with 1/5 dose of long-term regimen and compared with the previous data. Results Patients in the 1/5 dose long-term cycle had significantly higher age, Gn activation and total Gn days, serum E2 level on HCG day, number of follicles ≥ 14 mm, number of oocytes retrieved, number of available embryos and number of high quality embryos than in previous cycles; Rate, cleavage rate and high-quality embryos were increased (81.1% vs. 78.7%, 79.7% vs. 72.3%, 43.2% vs 34.0% respectively), but the difference was not significant. Patients in the 1/5 dosing regimen had a higher probability of ovarian cysts (20%, 6/30). Conclusion A one-fifth dose long-term regimen improves ovarian response in patients with poor ovarian response and may improve egg quality.