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目的:观察胺碘酮治疗室性心律失常治疗时程对心电图T波顶点至T波终点的宽度(T-peak to T-end inter-val,TpTe)的影响。方法:85例室性心律失常患者,胺碘酮150 mg静脉注射,继以1 mg/kg,持续6 h,后减量至0.5mg/kg,持续48 h后停用,静脉胺碘酮24 h后,开始同时加用口服胺碘酮,每次0.2 g,1日3次,1周;每次0.2 g,每日2次,1周;0.2 g每日1次维持,观察用药后1、3、7、10、14、17、21 d心率、TpPe、QT、TpPe-c、QTc变化。结果:心律失常控制率达92%(78/85)。治疗有效组自治疗后第1天心率明显减慢,QT间期明显延长(P≤0.01),14 d时达最大值,后趋于平稳,但未见统计学意义差异。但整个治疗时程中胺碘酮对TpTe、TpTe-c及QTc未见有统计学意义的改变。结论:胺碘酮治疗室性心律失常不影响TpTe,TpPe独立于心率,不需要心率校正。
Objective: To observe the effect of duration of amiodarone on T-peak to T-end inter-val (TpTe) in patients with ventricular arrhythmia. Methods: Eighty-five patients with ventricular arrhythmias received amiodarone 150 mg intravenously, followed by 1 mg / kg for 6 h and then reduced to 0.5 mg / kg for 48 h before discontinuation. Intravenous amiodarone 24 h, began with oral administration of amiodarone at the same time, each 0.2 g, 1 3 times a week; each 0.2 g, 2 times a day for 1 week; 0.2 g daily maintenance of 1 observed after treatment 1 , 3,7,10,14,17,21 d heart rate, TpPe, QT, TpPe-c, QTc changes. Results: The rate of arrhythmia control was 92% (78/85). On the first day after treatment, the effective rate of treatment group was significantly slowed down, the QT interval was significantly prolonged (P≤0.01), the maximum value was reached on the 14th day and then stabilized, but no statistical difference was found. Amiodarone did not show any significant change in TpTe, TpTe-c and QTc throughout the course of treatment. Conclusion: Amiodarone does not affect TpTe in the treatment of ventricular arrhythmias. TpPe is independent of heart rate and does not require heart rate correction.