研究了血浆纤维粘连蛋白（Ｆｎ）对培养的巨噬细胞（ＭΦ）吞噬结核杆菌（ＴＢ）的影响。结果显示：抗Ｆｎ血清与抗Ｃ３血清可显著降低ＭΦ的吞噬水平，抑制率分别达４８％±１％和６９％±１％；两者联用使抑制效应进一步增强，抑制率达８８％±１％；增加Ｆｎ作用剂量与时间，ＭΦ对ＴＢ吞噬力亦随之增强。上述表明Ｆｎ与Ｃ３是血清中增强ＭΦ吞噬ＴＢ的主要分子，Ｆｎ可不依赖补体单独发挥促ＭΦ吞噬的作用。 The effect of fibronectin (Fn) on phagocytosis of M. tuberculosis (MΦ) by cultured macrophages was studied. The results showed that anti-Fn serum and anti-C3 serum could significantly reduce phagocytosis of MΦ, the inhibition rates were 48% ± 1% and 69% ± 1%, respectively; the combination of the two could further enhance the inhibitory effect to 88% ± 1%; increasing dose and time of Fn, MΦ also increased phagocytosis of TB. The above shows that Fn and C3 are the main molecules that enhance the phagocytosis of MΦ in serum, and Fn can play the role of promoting MΦ phagocytosis independent of complement.