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目的:观察醋酸肠道刺激对大鼠肠道高敏感性的影响及其可能影响因子。方法:采用醋酸慢性刺激建立肠道高敏感性大鼠模型,观察大鼠肠道敏感性以及结肠黏膜下P物质、5-羟色胺免疫反应阳性纤维的变化.结果:醋酸注射直肠能够引起实验动物的腹壁撤离反射的阈值降低;肠道内的P物质含量低于对照组(P<0.01),肠道粘膜下的5-羟色胺免疫阳性神经元/神经纤维阳性指数(IOD)显著增加(P<0.01);结论:醋酸直肠慢性刺激可导致肠道高敏感性,其机制可能与引起5-HT免疫阳性神经纤维增加、P物质分泌紊乱有关。
Objective: To observe the effect of acetic acid gut stimulation on intestinal hypersensitivity in rats and its possible influence factors. Methods: Chronic hyperalgesia rat model was established by acetic acid and the intestinal sensitivity and the changes of substance P and serotonin-immunoreactive fibers in the colon mucosa were observed.Results: Acetate injected into the rectum could induce the growth of experimental animals (P <0.01). The serotonergic immunoreactive neurons / nerve fiber positive index (IOD) in the intestinal mucosa significantly increased (P <0.01) ; Conclusion: Chronic acetic rectal stimulation can lead to intestinal hypersensitivity. The mechanism may be related to the increase of 5-HT-positive immunoreactive nerve fibers and the imbalance of substance P secretion.