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癌性胸膜炎的治疗,以往常常是将各种抗癌药,类固醇激素或非类固醇性抗炎剂注入胸腔内,但都未能得到满意效果。1972年 Rubinson 等在12例癌性胸膜炎患者的胸膜腔内插入引流管进行持续排液,然后注入500mg 四环素,并夹住引流管停止排液6小时,再后拔除引流管,结果10例获得显效。Thorsrud 用鼠和兔作动物实验,探讨空气、滑石粉、细菌毒素、噻替哌、四环素对胸膜间皮的影响,证实四环素效果
The treatment of cancerous pleurisy used to inject various anticancer drugs, steroid hormones or nonsteroidal anti-inflammatory agents into the thoracic cavity. However, no satisfactory results were obtained. In 1972, Rubinson et al. inserted drainage tubes into the pleural cavity of 12 patients with cancerous pleurisy for continuous drainage. Then 500 mg of tetracycline was injected. The drainage tube was clamped to stop the drainage for 6 hours. Then the drainage tube was removed and the result was markedly improved in 10 cases. . Thorsrud used rats and rabbits as animal experiments to investigate the effects of air, talc, bacterial toxins, thiotepa, and tetracycline on the pleural mesothelium, confirming the effect of tetracycline