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目的探讨年龄30岁以下卵巢恶性肿瘤患者的临床特点、病理类型、治疗方案及预后。方法回顾性分析2010年1月至2015年1月间就诊于中国人民解放军总医院、年龄位于30岁以下的139例卵巢肿瘤患者的临床资料,对其发病特征,病理类型,手术方式,术后辅助化疗进行分析。结果有明显临床症状就诊者占87.77%(122/139),卵巢恶性肿瘤病理分类包括上皮性肿瘤58例(41.73%)、生殖细胞肿瘤79例(56.83%)、性索间质肿瘤1例(0.72%)、转移性肿瘤1例(0.72%)。手术病理分期:Ⅰ期103例,Ⅱ期13例,Ⅲ期18例,Ⅳ期5例。109例行保留生育功能手术。127例行术后辅助化疗。随访超过24个月的患者中65例无瘤生存,复发8例,5例死亡;66例月经化疗后恢复正常,33例有生育计划的患者中21次妊娠,11例足月分娩。结论卵巢癌病理类型与年龄相关,幼女及青少年是生殖细胞为主。卵巢恶性肿瘤临床手术病理分期早期,手术应尽可能保留生育功能。应重视年卵巢疾病的临床表现并定期妇科检查,早期诊治可有效改善预后。
Objective To investigate the clinical features, pathological type, treatment and prognosis of ovarian cancer patients under 30 years of age. Methods A retrospective analysis of clinical data of 139 patients with ovarian tumors who visited the PLA General Hospital from January 2010 to January 2015 and whose age was under 30 years old was performed. The clinical features, pathological types, surgical methods, Adjuvant chemotherapy was analyzed. Results There were 87.77% (122/139) patients with clinically obvious symptoms, 58 (41.73%) with epithelial tumors, 79 (56.83%) with germ cell tumors and 1 with interstitial stromal tumors 0.72%), metastatic tumor in 1 case (0.72%). Surgical staging: Ⅰ stage in 103 cases, Ⅱ in 13 cases, Ⅲ in 18 cases, Ⅳ in 5 cases. 109 routine maintenance of reproductive function surgery. 127 cases of postoperative adjuvant chemotherapy. Sixty-five patients survived for more than 24 months, with 8 patients relapsed and 5 dead. Sixty-six patients returned to normal after menstruation and chemotherapy, and 21 were delivered in 33 patients with fertility plans and 11 were delivered in full term. Conclusions The pathological type of ovarian cancer is related to age, young girls and adolescents are mainly germ cells. Early stage of ovarian cancer surgical staging, surgery should retain reproductive function as much as possible. Should pay attention to the clinical manifestations of ovarian disease and regular gynecological examination, early diagnosis and treatment can effectively improve the prognosis.