The aim of this study was to determine the epidemiologic characteristics and prognostic factors in young patients (＜30 y.o.) with colon cancer.The Surveillance,Epidemiology,and End Results (SEER) registry database,a US population-based cancer registry database,was used to identify all patients diagnosed with colon cancer from 2010 to 2015.Cox proportional-hazards regression was used analysis to evaluate the association between the patients registry database,and to identify all patients diagnosed with c race,AJCC stage,treatment methods,primary tumor site,differentiation grade and histological type.A total of 554 patients were diagnosed with colon cancer when younger than 30 years old.The overall rate of distant metastasis in the cohort was 28.5％.The majority of neoplasms were found in whites/Caucasians (75.8％),while the incidence in Black/African-American patients was relatively low (12.7％).A large proportion of tumors were located in the sigmoid colon (35.9％),followed by the descending colon,ascending colon and transverse colon.Grade Ⅲ/Grade Ⅳ (HR =1.74;95％CI,1.38 to 3.20),distant metastasis (HR =5.25;95％CI,2.44 to 7.86),no surgery (HR =5.25;95％CI,2.44 to 7.86),and mucous/signet-ring cell histology (HR =2.49;95％CI,2.15 to 2.94) were independent risk factors for reduced survival in the analysis.The tumor location (P =0.71),race (P =0.52) and gender (P =0.41) were not major factors affecting the overall survival rate.This study revealed the distinct clinic pathological features of colon cancer patients younger than 30 years old.Poorly differentiated tumors,non-surgical treatment,and distant metastasis indicated a worse prognosis and overall survival.