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近年来研究认为细胞介导的细胞毒作用(cellmediatedcytoxicity,CMC)是病毒性心肌炎心肌损伤的主要原因,而Fas/FasL途径是CMC致靶细胞损伤的途径之一,可以直接介导心肌细胞凋亡或作用于免疫系统,从而引起心肌损伤。Fas/FasL途径是病毒性心肌炎持续心肌损伤及其发展而成的扩张型心肌病的重要机制。
Recent studies suggest that cell-mediated cytotoxicity (CMC) is the main cause of myocardial damage in viral myocarditis. Fas / FasL pathway is one of the pathways of CMC-induced target cell injury and can directly mediate cardiomyocyte apoptosis Or act on the immune system, causing myocardial damage. The Fas / FasL pathway is an important mechanism of sustained myocardial injury and its development of dilated cardiomyopathy in viral myocarditis.