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淋巴细胞在特异性抗原或非特异性刺激物植物血凝素(PHA)等刺激下,转化成为具有很强分裂能力的淋巴母细胞,是为转化试验。健康人血液淋巴细胞对PHA的母细胞生成率,有资料介绍为64.4±27％(成年人)及64.8±29％(小儿)。在下列情况下可检出生成率降低:①先天性免疫缺损病;②恶性肿瘤(特别是网状内皮系统的肿瘤)及自身免疫病;③传染病如麻疹;④消耗性疾患;⑤Down综合症;⑥药剂的影响如激素类、抗肿瘤药物的影响等。此试验较为简便,临床上应用于检验免疫缺损病、检验细胞免疫能力以及观
Lymphocytes are transformed into lymphoblasts with strong ability to divide under the stimulation of specific antigens or non-specific stimulators such as phytohemagglutinin (PHA) and so on. Healthy human blood lymphocytes to PHA of the blastocyst rate, there are data described as 64.4 ± 27% (adults) and 64.8 ± 29% (pediatric). Decreased productivity can be detected in the following cases: (1) congenital immunodeficiency disease; (2) malignancy (especially reticuloendothelial system tumors) and autoimmune diseases; (3) infectious diseases such as measles; (4) wasting disorders; (5) Down Syndrome ; ⑥ effects of agents such as hormones, anti-cancer drugs and so on. This test is relatively simple, clinically used to test immunodeficiency disease, test cellular immunity and the concept of