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目的通过检测肝细胞生长因子(HGF)和人Ⅱ型肺泡细胞表面抗原(KL-6)在原发性干燥综合征(PSS)并肺间质病变(PSS-ILD)患者血清中的表达水平,探讨其在PSS-ILD中的意义。方法采用ELISA法检测120例PSS(包括54例PSS-ILD)和36例健康体检者血清HGF,KL-6的表达水平。结果 PSS-ILD组中HGF含量低于非肺间质病变组和正常对照组,而KL-6的含量高于非肺间质病变组和正常对照组,差异均有统计学意义(P<0.05),两者之间呈负相关;HGF和KL-6对PSS-ILD诊断的灵敏度、特异度分别为(86.0%,92.1%)、(62.4%,61.2%)。结论 HGF和KL-6参与PSS-ILD的发生发展过程,可作为早期筛查PSS-ILD的指标之一,同时可能为PSS-ILD的治疗提供一种新的方法。
Objective To detect the expression of hepatocyte growth factor (HGF) and human type II alveolar cell surface antigen (KL-6) in the serum of patients with primary Sjogren’s syndrome (PSS) and interstitial lung disease (PSS-ILD) To explore its significance in PSS-ILD. Methods The serum levels of HGF and KL-6 in 120 patients with PSS (including 54 PSS-ILD) and 36 healthy controls were detected by ELISA. Results The level of HGF in PSS-ILD group was lower than that in non-interstitial lung disease group and normal control group, while the content of KL-6 in PSS-ILD group was higher than that in non-interstitial lung disease group and normal control group (P <0.05 ). The sensitivity and specificity of HGF and KL-6 for the diagnosis of PSS-ILD were (86.0%, 92.1%) and (62.4%, 61.2%, respectively). Conclusions HGF and KL-6 are involved in the pathogenesis of PSS-ILD, which may be used as an early marker of PSS-ILD screening and may provide a new method for the treatment of PSS-ILD.