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1960年Tursky发现氰化钾中毒大白鼠脑的γ-氨基丁酸含量显较正常动物为低,但谷氨酸水平则显著升高。脑的γ-氨基丁酸系由谷氨酸经脱羧基作用产生者。此反应系由I-谷氨酸脱羧酶催化。γ-氨基丁酸之代谢则系首先通过与α-酮戊二酸的转氨基作用,生成琥珀酸半醛和谷氨酸。最近,Simonsen等曾证实由小白鼠脑谷氨酸脱羧酶分子中有敏感的-SH基存在。另外作者则已证实I-谷氨酸脱羧酶和γ-氨基丁酸-α-酮戊二酸转氨酶两者均为磷酸吡哆醛酶。
1960 Tursky found that potassium cyanide intoxication in rats brain γ-aminobutyric acid content was significantly lower than normal animals, but glutamate levels were significantly higher. Gamma-aminobutyric acid brain is produced by the decarboxylation of glutamate. This reaction is catalyzed by I-glutamate decarboxylase. The metabolism of γ-aminobutyric acid is first of all formed by the transamination with α-ketoglutaric acid to form succinic semialdehyde and glutamic acid. Recently, Simonsen et al. Demonstrated the presence of a sensitive -SH group in the mouse glutamate decarboxylase molecule. In addition, the authors have demonstrated that both I-glutamate decarboxylase and gamma-aminobutyric acid-alpha-ketoglutarate aminotransferase are pyridoxal phosphate phosphates.