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妊娠肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)是发生在妊娠中晚期,以皮肤瘙痒、黄疸、血清胆汁酸升高,伴轻度肝功能损害为特征的妊娠并发症,严重影响母儿健康。ICP的发病机制尚未完全阐明,但有研究表明在遗传易感性妇女中,性激素及其代谢产物导致胆汁酸代谢异常与本病的发生密切相关。现就目前国内外有关ICP发病机制的研究进展做一综述,一方面为探寻更深层次的机制提供理论基础,另一方面为临床治疗ICP提供思路和方法。
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy complication characterized by pruritus, jaundice, elevated serum bile acid, and mild hepatic dysfunction that occurs in the second and third trimester of pregnancy, health. The pathogenesis of ICP has not yet been fully elucidated, but studies have shown that in women with genetic predisposition, abnormalities in bile acid metabolism caused by sex hormones and their metabolites are closely related to the occurrence of this disease. Now on the current domestic and international research on the pathogenesis of ICP to make a review of the progress, on the one hand to explore a deeper mechanism to provide the theoretical basis, on the other hand provide ideas and methods for clinical treatment of ICP.