目的:在美国,每年有HBsAg阳性的产妇分娩约25 000个新生儿。推荐新生儿出生时立即注射乙肝疫苗和乙肝免疫球蛋白,随后完成疫苗接种及进行血清学检测。在较大队列的HBsAg阳性产妇分娩的婴儿中评估了影响疫苗应答的因素。方法:研究对象为2008-2013年间围产期乙肝预防计划内HBsAg阳性产妇分娩的HBsAg阴性的婴儿。接种不少于3剂疫苗后,婴儿乙肝表面抗体 Purpose: In the United States, about 25,000 newborns give birth each year to HBsAg-positive mothers. It is recommended that newborns be given hepatitis B vaccine and hepatitis B immunoglobulin immediately after their birth, followed by vaccination and serological testing. Factors affecting vaccine response were evaluated in larger cohorts of infants born to HBsAg-positive mothers. METHODS: Subjects were HBsAg-negative infants born during the HBeAg-positive mothers within perinatal hepatitis B prevention program during 2008-2013. After vaccination of not less than 3 doses of vaccine, the infant hepatitis B surface antibody