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目的了解肥胖儿童治疗前后体格指标和血脂、瘦素和超敏C-反应蛋白(high-sensitivity C-reactive protein,hCRP)的变化。方法对12～15岁单纯性肥胖儿童予以饮食控制加运动进行6个月治疗,比较治疗前后体格发育指标、血脂、瘦素和hCRP的变化。结果体重和体质指数(body mass index,BMI)明显下降(P<0.05);TC、LDL-C、TG和hCRP浓度亦明显下降(P<0.05);HDL-C和瘦素浓度无明显变化(P>0.05)。结论对肥胖儿童进行运动和限制饮食治疗会改善血脂和hCRP等与成人心血管疾病密切相关的危险因素。
Objective To investigate the changes of physical parameters and the levels of serum lipids, leptin and high-sensitivity C-reactive protein (hCRP) in obese children before and after treatment. Methods The obese children aged 12-15 years were given diet control and exercise for 6 months. The physical development indexes, serum lipids, leptin and hCRP before and after treatment were compared. Results Body weight index and body mass index (BMI) decreased significantly (P <0.05), TC, LDL-C, TG and hCRP concentrations also decreased significantly P> 0.05). Conclusion Exercise and diet restriction in obese children may improve risk factors such as blood lipids and hCRP, which are closely related to cardiovascular disease in adults.