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[目的]探讨全麻下经皮椎体后凸成形术的安全性.[方法] 85例患者,按麻醉方式分为局麻组42例,全麻组43例,两组均通过术前影像设计精确穿刺路径经单侧椎弓根旁入路完成手术.比较两组手术前后VAS评分、Oswetry评分及椎体高度、Cobb角.分析两组麻醉效果,麻醉不良反应率以及患者对麻醉手术的满意度和耐受度.[结果]共有71例患者完成12～15个月随访.影像评估、VAS评分及ODI值,手术前后比较差异有统计学意义(P＜0.05).全麻组麻醉满意率100％,全麻组与局麻组麻醉效果的比较,差异有统计学意义(P＜0.05).局麻组共2例患者改为全麻.全麻组满意度和耐受度高,不良反应低,与局麻组比较,差异有统计学意义(P＜0.05).两组均无肺栓塞、感染、神经损害等并发症.[结论]经过术前个体化设计手术路径、术中仔细分析透视影像,在全麻下行经皮后凸成形术治疗椎体压缩性骨折是安全有效的.“,”[Objective] To investigate the safety and effectiveness of the percutaneous kyphoplasty under the general anesthesia.[Methods] A total of 85 patients who underwent percutaneous kyphoplasty were divided into two groups,which included 42 patients applied local anesthesia (the LA group),while the remaing 43 patients received general anesthesia (the GA group).The patients in the both groups underwent the operation by CT-images designed puncture approach.The preoperative and postoperative VAS score,ODI score,vertebral height and Cobb angle were recorded.Additionally,the incidence of adverse reactions of anesthesia,as well as the satisfaction degree and the tolerance degree of patients were evaluated and compared between the two groups.[Results] Of the 85 patents,71 patients were followed up from 12 months to 15 months.There were significant improvements in the imaging measures,VAS and ODI compared the data before and after operation in the both groups (P＜0.05),however,no significant difference was noted between the two groups in any time point (P＞0.05).During operation,2 patients in the LA group were changed over to GA.The anesthesia satisfaction rate in GA group was 100％,showing a significant difference compared with the LA group (P＜0.05).The anesthetic effect of the GA group was better than that of LA group.In addition,the sedation and analgesia in the GA group was better after the operation,where it was statistically significant compared with the result of the LA group (P＜0.05).Furthermore,the patients in the GA group had higher satisfaction and tolerance to operation,associated with lower adverse reactions than the LA group,where the differences were statistically significant (P＜0.05).No pulmonary embolism,infection,nerve damage and other complications occurred in any patients of the both groups.[Conclusion] With assistance of individually designed approach preoperatively and careful analysis of intraoperative fluoroscopy images,percutaneous kyphoplasty is safe and effective under general anesthesia for treatment of vertebral compression fractures.