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目的:优选川芎最佳超微振动提取工艺。方法:以盐酸川芎嗪和阿魏酸为测定指标,采用正交试验设计法优化超微振动提取的次数、时间和溶剂用量,并与常规乙醇回流提取工艺进行比较。结果:川芎超微振动提取最佳工艺为药材粗粉加4倍量90%的乙醇超微振动提取,室温提取2次,每次15 min。在此条件下,与常规乙醇回流提取工艺相比,提取时间缩短为原来的1/6,溶剂用量为4/7,盐酸川芎嗪和阿魏酸提取率分别为常规工艺的1.19,1.09倍。结论:超微振动提取时间短、溶剂用量少、有效成分提取率高,具有工业化推广的前景。
Objective: Optimize the extraction of Chuanxiong optimum ultra-micro vibration. Methods: Taking tetramethylpyrazine hydrochloride and ferulic acid as the determination indexes, the orthogonal experiment design method was used to optimize the number of ultra-micro vibration extraction, the time and the solvent dosage, and compared with the conventional ethanol reflux extraction process. Results: The optimal extraction process of Chuanxiong by ultra-micro vibration was extracting with 4 times the amount of 90% ethanol by ultrafine vibration and twice at room temperature for 15 minutes. Under these conditions, the extraction time was shortened to 1/6 and the solvent was 4/7 compared with the conventional ethanol reflux extraction. The extraction rates of ligustrazine and ferulic acid were 1.19 and 1.09 times of the conventional ones, respectively. Conclusion: The ultra-micro vibration extraction time is short, solvent consumption is small, the extraction rate of active ingredients is high, with the prospect of industrialization.