脑脊液嗜中性白细胞持续增高的脑膜炎(Persistent Neutrophilic Meningitis 下称PNM)系指一组 CSF 中嗜中性白细胞及蛋白增高,糖降低持续1周以上,伴有脑膜炎症状,但病原学检查阴性的慢性脑膜炎。以往 PNM 报告甚少,本文报告 PNM4例并对有关文献进行了复习。作者报告的4例患者中,3例死亡,1例存活,其中枢神经系统症状及 CSF 嗜中性白细胞增高持续14、209、32及25天不等。病程中进行多次 CSF 细菌涂片及培养,均为阴性,仅1例死后从 CSF 培养出金黄色 Cerebrospinal fluid neutrophil meningitis (Persistent Neutrophilic Meningitis, hereinafter referred to as PNM) refers to a group of neutrophils CSF and protein increased, the sugar decreased for more than 1 week, accompanied by meningitis, but the negative etiology Chronic meningitis. Previous PNM reports rarely, this article reports PNM4 cases and reviewed the literature. Of the 4 patients reported by the authors, 3 died and 1 survived, with central nervous system symptoms and CSF neutrophilia increasing for 14,209,32 and 25 days. During the course of multiple CSF bacterial smear and culture, were negative, only 1 patient died from CSF cultured golden yellow