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目的 :观察小剂量持续胃肠透析治疗尿毒症的效果。方法 :5 8例尿毒症患者随机分为两组 ,治疗组口服胃肠透析液 ,每次 10 0 0ml,每天 3次 ,对照组口服包醛氧化淀粉 ,每次 5～ 10 g ,每天 3次 ,疗程 3个月。结果 :与治疗前及对照组相比 ,小剂量持续胃肠透析治疗后 ,患者的临床症状改善 ,生活质量提高 ,营养状况良好 ,血肌酐、尿素氮、血磷、血尿酸水平明显下降 ,内生肌酐清除率水平明显升高 (P <0 .0 1)。对照组治疗前后上述指标无明显变化。两组病人的血压、体重、血浆总蛋白、血浆白蛋白、2 4h尿蛋白及尿量治疗前后均无明显改变。结论 :小剂量持续胃肠透析治疗尿毒症疗效显著 ,为慢性肾功能衰竭 (CRF)的非替代疗法增加了一个新的治疗手段
Objective: To observe the effect of continuous low-dose gastrointestinal dialysis on uremia. Methods: Fifty-eight patients with uremia were randomly divided into two groups. The treatment group was orally administered dialysate orally in a volume of 100 ml daily for 3 times. The control group was orally administered with aldose oxidized starch (5-10 g each time, 3 times daily) , Treatment for 3 months. Results: Compared with pre-treatment and control group, the clinical symptoms, quality of life, nutritional status and serum creatinine, blood urea nitrogen, blood phosphorus and serum uric acid levels were significantly decreased after continuous low-dose gastrointestinal dialysis treatment Creatinine clearance was significantly higher (P <0.01). The control group before and after treatment the above indicators no significant change. Blood pressure, body weight, total plasma protein, plasma albumin, 24 h urinary protein and urine volume in two groups had no significant changes before and after treatment. CONCLUSIONS: Small doses of continuous gastrointestinal dialysis have a significant therapeutic effect on uremia and a new treatment for non-replacement therapy of chronic renal failure (CRF)