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目的:探讨血清内脂素水平与糖尿病并发冠心病的关系。方法:将69例2型糖尿病患者根据冠状动脉造影管腔直径是否狭窄(50%)及狭窄是否超过70%分为冠状动脉阴性组(27例),非显著狭窄组(19例)和显著狭窄组(23例),并入选正常对照者(25例)分别测定内脂素浓度并进行比较。结果:冠状动脉显著狭窄组血清内脂素浓度显著高于对照组和冠状动脉阴性组(P<0.01)。但冠状动脉非显著狭窄组和显著狭窄组之间内脂素浓度差异无统计学意义(P>0.05)。结论:糖尿病患者血清内脂素水平与冠心病发生及病变严重程度显著相关。
Objective: To investigate the relationship between serum visfatin and diabetes with coronary heart disease. Methods: Sixty-nine patients with type 2 diabetes were divided into coronary-negative group (n = 27), non-conspicuous group (n = 19) and significant stenosis according to whether coronary artery stenosis (50%) and stenosis were over 70% (N = 23) were enrolled in the control group (n = 25). The concentration of visfatin was measured and compared. Results: The serum visfatin concentration in stenosis group was significantly higher than that in control group and coronary artery negative group (P <0.01). However, there was no significant difference in the concentration of visfatin between nonsignificant stenosis group and stenosis group (P> 0.05). Conclusion: The level of serum visfatin in patients with diabetes is significantly correlated with the occurrence of coronary heart disease and the severity of the disease.