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为探讨潜阳方治疗高血压肝阳上亢证大鼠模型的药效学基础，采用双肾双夹加灌附子汤法复制高血压肝阳上亢证大鼠模型，观察潜阳方的疗效及对其血浆去甲肾上腺素（ＮＥ）、肾上腺素（Ｅ）、血管紧张素Ⅱ（ＡｎｇⅡ）及脑干ＮＥ、５－羟色胺（５－ＨＴ）的影响，并与西药卡托普利进行对比。结果显示潜阳方、卡托普利均能减轻模型大鼠的各种症状，而以前者效果较佳；二者均能显著降低模型大鼠血压，而以后者为优；二者均能使模型大鼠血浆ＮＥ、Ｅ及脑干ＮＥ降至正常，前者可同时升高脑干５－ＨＴ，而后者降低血浆ＡｎｇⅡ作用明显优于前者。提示潜阳方降低实验动物血压、减轻肝阳上亢症状的机制可能与降低血浆ＮＥ、Ｅ及脑干ＮＥ和升高脑干５－ＨＴ含量有关
To investigate the pharmacodynamic basis of Qianyang Recipe in the rat model of hypertensive liver-yang hyperactivity syndrome, double-kidney double-clip plus Guanzizi decoction was used to replicate hypertensive rat model of liver-yang hyperactivity syndrome and observe the curative effect of Qianyang decoction. And its plasma norepinephrine (NE), epinephrine (E), angiotensin II (AngII) and brain stem NE, 5-hydroxytryptamine (5-HT), and compared with western medicine captopril . The results showed that Qianyangfang and captopril all reduced the symptoms of the model rats, but the former had better results; both of them could significantly reduce the blood pressure of the model rats, while the latter was excellent; both could make The levels of plasma NE, E and brain stem NE in model rats were reduced to normal. The former can increase brain stem 5-HT, while the latter is significantly better than the former in reducing plasma AngII. It is suggested that the mechanism by which Qianyang Recipe reduces blood pressure in experimental animals and alleviates symptoms of liver-yang hyperactivity may be related to the decrease of plasma NE, E, brain stem NE, and elevation of 5-HT content in brain stem.