肾素血管紧张素系统(RAS)是人体血压与林液调节中一种十分重要的生理机制。该系统主要来源于肾、肝、肺等不同脏器的肾素、血管紧张素(ANG)和血管紧张素转化酶。其主要活性成分ANGⅡ具有众多靶器官,如心、脑、肾、血管等。现有研究表明,这些靶器官不仅含有ANGⅡ受体,同时还可能具有独立的局部RAS。最近,Aguirela和Fei等所做的工作,有力地证明局部RAS的存在和具有的功能意 The renin-angiotensin system (RAS) is a very important physiological mechanism in the regulation of blood pressure and fluid in the human body. The system mainly comes from renin, angiotensin (ANG) and angiotensin converting enzyme in different organs such as kidney, liver and lung. Its main active ingredient ANG Ⅱ has many target organs, such as heart, brain, kidney, blood vessels and so on. Existing research shows that these target organs not only contain ANG Ⅱ receptors, but also may have independent local RAS. Recently, the work done by Aguirela and Fei et al. Has strongly proved the existence and function of the local RAS