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人乳头瘤病毒的基因表达与 KC的增殖分化相互影响。近二十年来人们在如何体外重复两者之间的关系方面做了大量工作 ,但由于体外培养人乳头瘤病毒非常困难 ,因此有关实验多是采用体外培养的人乳头瘤病毒相关肿瘤细胞系作为研究对象。本文的内容包括 (1) HPV相关细胞系体外培养的方法 ;(2 )有关影响人乳头瘤病毒相关细胞系增殖的细胞因子和药物 ,及其作用机理。
The gene expression of human papillomavirus interacts with the proliferation and differentiation of KC. Much work has been done on how to repeat the relationship between the two in vitro and in vivo in the past two decades. However, since it is very difficult to culture human papillomavirus in vitro, many experiments have been conducted on in vitro cultured human papillomavirus-associated tumor cell lines Research object This article includes (1) methods of in vitro culture of HPV-related cell lines; (2) cytokines and drugs that affect the proliferation of human papillomavirus-associated cell lines and their mechanism of action.