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目的:通过在对照组上加用自拟方进行中药灌肠,探讨中药灌肠对CKD3~4期患者肾功能的改善情况以及其对血清中分子尿毒症毒素β2-MG的清除情况。方法:对符合要求的病人随机分为对照组和灌肠组,观察灌肠后12周的临床指标。结果:灌肠组12周后中医证候改善的总有效率明显优于对照组(P<0.05),并且对于血中SCr、BUN以及β2-微球蛋白的浓度的降低也明显优于对照组(P<0.05)。结论:中药灌肠可有效改善患者肾功能情况,并进一步说明本自拟方中药灌肠不仅可以降低血中SCr、BUN等小分子尿毒症毒素的浓度,更可以降低血中β2-微球蛋白等中分子尿毒症毒素的浓度。可有效配合血液透析滤过等肾脏替代治疗。
OBJECTIVE: To study the improvement of renal function in patients with CKD stages 3-4 and its clearance of serum uremic toxins β2-MG by adding Chinese herbs enema in the control group. Methods: To meet the requirements of patients were randomly divided into control group and enema group, observed after 12 weeks of clinical enema enema. Results: The total effective rate of TCM syndromes after 12 weeks in the enema group was significantly better than that in the control group (P <0.05), and the decrease of SCr, BUN and β2-microglobulin in blood was also significantly better than that of the control group P <0.05). Conclusion: The traditional Chinese medicine enema can effectively improve the renal function of patients, and further explain the self-made prescription enema can not only reduce blood SCr, BUN and other small molecule uremic toxins concentration, but also can reduce blood β2-microglobulin Molecular uremic toxins concentration. Can effectively cooperate with hemodialysis and other renal replacement therapy.