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肿瘤细胞内酵解酶的活性增强，是造成其异常代谢和出现恶病质的主要原因，降低肿瘤细胞的酵解酶活性对纠正肿瘤细胞的异常代谢具有重要意义。本实验应用次黄嘌呤核苷对ＢＧＣ－８２３人胃癌细胞株作用，结果显示：次黄嘌呤核苷作用后，培养肿瘤细胞内的乳酸脱氢酶反应颗粒较对照组明显减少或消失，细胞数目减少，细胞结构改变。大剂量药物作用时，出现细胞变小及萎缩现象。结果表明，次黄嘌呤核苷可抑制ＢＧＣ－８２３人胃癌细胞株酵解酶的活性，阻断肿瘤细胞主要的能量来源，调整其异常糖代谢过程，并促进机体竞争代谢底物，从而改善肿瘤患者的恶病质状况。
The enhanced activity of intracellular glycolytic enzymes is the main cause of their abnormal metabolism and cachexia. Decreasing the glycolytic enzyme activity of tumor cells is of great significance in correcting the abnormal metabolism of tumor cells. In this experiment, hypoxanthine was used to treat BGC-823 human gastric cancer cell lines. The results showed that after the action of hypoxanthine, the lactate dehydrogenase reaction particles in the cultured tumor cells were significantly reduced or disappeared compared to the control group, and the number of cells was decreased. Decrease, cell structure changes. When large-dose drugs act, cells become smaller and shrink. The results showed that hypoxanthine inhibited the activity of glycolytic enzyme of BGC-823 human gastric cancer cell line, blocked the main energy source of tumor cells, adjusted its abnormal glycometabolism, and promoted the body to compete for metabolic substrates, thereby improving tumors. The patient’s cachexia status.