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目的 探讨SARS患者外周血T淋巴细胞亚群的变化及其临床意义。方法 用全自动血细胞分析仪检测 4 4例SARS患者外周血白细胞计数及分类 ,用流式细胞仪检测SARS患者外周血T淋巴细胞亚群 ;并与正常对照组比较。结果 与对照组比较 ,SARS组患者白细胞总数显著下降 ,淋巴细胞百分数和绝对数显著下降 ,粒细胞绝对数显著下降 ,粒细胞百分数显著增加 ;CD3+ 、CD4 + 和CD8+ 细胞绝对数显著下降 ,CD3+ 、CD4 + 及CD8+ 细胞百分数和CD4 + CD8+ 比值与对照组比较无显著性差异。结论 SARS冠状病毒感染损伤患者细胞免疫功能。
Objective To investigate the changes of T lymphocyte subsets in peripheral blood of patients with SARS and its clinical significance. Methods Peripheral white blood cell count and classification of 44 cases of SARS were detected by automatic hematology analyzer. T lymphocyte subsets in peripheral blood of patients with SARS were detected by flow cytometry and compared with the normal control group. Results Compared with the control group, the total number of white blood cells in SARS patients decreased significantly, the percentage of lymphocytes and absolute number decreased significantly, the absolute number of granulocytes decreased significantly and the percentage of granulocytes increased significantly. The absolute numbers of CD3 +, CD4 + and CD8 + CD4 + and CD8 + cell percentage and CD4 + CD8 + ratio compared with the control group no significant difference. Conclusion The cellular immune function in SARS-coronavirus infected patients.