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为探讨空气负离子对免疫功能的影响及其作用机理，用雄性小鼠１３２只，随机分为６组。１、２、３组皮下注射生理盐水０．２ｍｌ，４、５、６组皮下注射环磷酰胺１００ｍｇ／ｋｇ；２、５组和３、６组分别暴露于不同浓度的空气负离子［（１０±５）×１０１０个／ｍ３和（５０±５）×１０１０个／ｍ３］，每ｄ２次，每次２ｈ。在实验进行至１５ｄ时，各组随机处死一半动物，在３０ｄ时，处死另一半动物；测定动物脑组织５－羟色胺含量、中性白细胞吞噬率、血清溶菌酶、白细胞总数、Ｅ－玫瑰花结率等指标。结果显示：①染毒组吸入空气负离子后，脑组织中５－羟色胺含量显著降低（Ｐ＜０．０５）；②空气负离子能减轻环磷酰胺对动物免疫功能的抑制作用。结果提示：空气负离子对异常的免疫功能有一定恢复作用，而对正常的免疫功能影响不明显。
To investigate the effect of air negative ions on immune function and its mechanism of action, 132 male mice were randomly divided into 6 groups. Groups 1,2,3 were subcutaneously injected with 0.2 ml saline, while groups 4, 5 and 6 were injected subcutaneously with cyclophosphamide 100 mg / kg. Groups 2, 3 and 3 were exposed to different concentrations of air negative ions [(10 ± 5) × 1010 / m3 and (50 ± 5) × 1010 / m3] every 2 times for 2 hours. Half of the animals were sacrificed at the end of the experiment until the 15th day, and the other half animals were sacrificed on the 30th day. Serum 5-HT, phagocytic rate of neutrophils, total lysozyme, white blood cells, E- Rate and other indicators. The results showed that: ①The levels of 5-hydroxytryptamine in brain tissues were significantly decreased after exposure to air negative ions (P <0.05); ② Air anion could reduce the inhibitory effect of cyclophosphamide on immune function. The results suggest that air negative ions have a certain recovery effect on abnormal immune function, but have no obvious effect on normal immune function.