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目的:研究乳癖消颗粒的抗炎、镇痛作用。方法:采用二甲苯致小鼠耳廓肿胀实验观察乳癖消颗粒的抗炎作用。采用醋酸致小鼠扭体反应实验和小鼠热板法实验观察乳癖消颗粒的镇痛作用。结果:与空白对照组相比,乳癖消颗粒低、中、高剂量组(生药量分别为1.0、2.0和4.0 g·kg·d-1)均能显著抑制小鼠耳肿胀度(P<0.05或P<0.001),且能显著减少醋酸引起的小鼠扭体反应次数(P<0.01或P<0.001);中、高剂量组可提高小鼠热板痛阈值(P<0.05或P<0.01)。结论:乳癖消颗粒具有显著的抗炎镇痛作用。
Objective: To study the anti-inflammatory and analgesic effects of Rupixiao granule. Methods: The anti-inflammatory effect of Rupixiao Granule was observed with xylene-induced auricle swelling in mice. The analgesic effect of Rupixiao granule was observed by acetic acid induced writhing reaction in mice and hot plate test in mice. RESULTS: Compared with the blank control group, Ruupixiao granules in low, medium and high dose groups (crude drug doses of 1.0, 2.0 and 4.0 g · kg · d-1, respectively) could significantly inhibit ear swelling in mice (P < 0.05 or P <0.001), and could significantly reduce the number of writhing reactions induced by acetic acid in mice (P <0.01 or P <0.001) 0.01). Conclusion: Rupixiao particles have significant anti-inflammatory and analgesic effects.