论文部分内容阅读
目的:分析小剂量丙戊酸联合拉莫三嗪对癫痫的临床治疗效果以及安全性。方法:选择重庆市长寿区人民医院于2015年3月至2016年4月收治均为的癫痫患者86例,根据其治疗药物的差异性划为观察组和对照组,将丙戊酸应用于对照组治疗中,将小剂量丙戊酸联合拉莫三嗪应用于观察组治疗中,分析两组患者的临床疗效以及安全性。结果:观察组治疗有效率95.35%和对照组治疗有效率76.74%,同时观察组不良反应发生率明显低于对照组组间比较,差异具有统计学意义(P<0.05)。结论:癫痫患者采用小剂量丙戊酸联合拉莫三嗪进行治疗,其效果良好,有助于其血药浓度的维持,进而提升患者用药的安全性。
Objective: To analyze the clinical efficacy and safety of low-dose valproate in combination with lamotrigine for epilepsy. Methods: From March 2015 to April 2016, 86 patients with epilepsy who were treated in Changshou District People’s Hospital of Chongqing were enrolled. According to the differences of therapeutic drugs, they were divided into observation group and control group. Valproic acid was used in control group Group therapy, the small dose of valproic acid combined with lamotrigine observed group treatment, analysis of two groups of patients with clinical efficacy and safety. Results: The effective rate of the treatment group was 95.35% and that of the control group was 76.74%. The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P <0.05). Conclusion: Epilepsy patients treated with low dose of valproic acid combined with lamotrigine have good effect, which is helpful to maintain the plasma concentration and further improve the safety of patients.