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目的比较氯吡格雷与阿司匹林治疗老年冠心病的临床疗效。方法选取2012年3月—2015年9月在常州市金坛区人民医院治疗的老年冠心病患者230例。按照数字表法分为观察组与对照组,各115例。两组患者均给予常规治疗,在此基础上观察组给予氯吡格雷治疗,对照组给予阿司匹林治疗。比较两组临床疗效、左心室射血分数(LVEF)、左室舒张末期内径(LVDED)、左室收缩末期内径(LVESD)的改善程度及不良反应发生率。结果观察组临床疗效优于对照组,治疗后LVEF、LVDED、LVESD高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论氯吡格雷与阿司匹林均能有效治疗老年冠心病,氯吡格雷具有更高的有效性、不良反应少,可更好的改善病情。
Objective To compare the clinical efficacy of clopidogrel and aspirin in the treatment of elderly patients with coronary heart disease. Methods From March 2012 to September 2015, 230 elderly patients with coronary heart disease were treated in Changzhou Jintan District People’s Hospital. In accordance with the digital table is divided into observation group and control group, each of 115 cases. Two groups of patients were given conventional treatment, on the basis of observation group were given clopidogrel treatment, the control group given aspirin treatment. The clinical efficacy, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDED), left ventricular end-systolic diameter (LVESD) and the incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group. The LVEF, LVDED and LVESD in the observation group were higher than those in the control group, and the incidence of adverse reactions was lower than that in the control group. The difference was statistically significant (P <0.05). Conclusion Both clopidogrel and aspirin can effectively treat elderly patients with coronary heart disease. Clopidogrel is more effective and has fewer adverse reactions, which can improve the condition.