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目的：研究原发性巴金森病（IPD）与多系统萎缩（MSA）交感神经皮肤反应（SSR），以探讨它们自主神经功能障碍的差异。方法：对31例IPD、17例MSA和83位正常人的SSR结果比较，分析PD组和MSA组SSR异常特征和与病程、自主神经症状的相关性。结果：MSA组SSR异常率（76％）显著高于IPD组（45％），以双侧异常多见。3年内病程的SSR异常率为73％，并与自主神经症状相关。IPD组SSR异常与病程显著相关，与自主神经症状无完全对应关系，SSR异常更多见于震颤侧。结论：MSA广泛而严重的自主神经系统受累可能是SSR异常显著有别于IPD的基础。SSR异常出现早，呈双侧改变，且与自主神经症状有对应关系，则更多提示MSA的可能。
OBJECTIVE: To study the sympathetic skin reaction (SSR) between primary Parkinson’s disease (IPD) and multiple system atrophy (MSA) to explore their differences in autonomic dysfunction. Methods: The SSR results of 31 cases of IPD, 17 cases of MSA and 83 normal subjects were compared, and the correlation between SSR abnormalities and the course of disease and autonomic nervous symptoms in PD group and MSA group was analyzed. Results: The abnormal rate of SSR in MSA group (76%) was significantly higher than that in IPD group (45%). The 3-year course of SSR abnormalities was 73% and associated with autonomic symptoms. The abnormality of SSR in IPD group was significantly correlated with the course of the disease, and there was no complete correspondence between the symptoms and autonomic symptoms. The abnormal SSR was more found in the tremor side. Conclusion: The extensive and severe MSA involvement may be the basis of abnormalities of SSR that are significantly different from IPD. SSR abnormalities appear early, showed bilateral changes, and the autonomic symptoms have a corresponding relationship, then more tips MSA possible.