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TCu380Ag是含铜IUD,LNg20是每天释放左旋18甲20μg的IUD。本文中作者报告了在美国、巴西、智利、埃及、新加坡、多米尼加等国的7个临床中心2,244名妇女使用上述二种IUD25个月的随机比较研究结果。研究对象为18～38岁要求置IUD的经产妇。按随机表分组,LNg20组1,124例,TCu380Ag组1,120例,采用单盲法,妇女不知道自己所置IUD的种类。结果表明置环困难LNg20组(14.7%)显著高于TCu380Ag组(3%),放置时中度或严重疼痛发生率LNg20组(18.8%)显著高于TCu380Ag组(10.8%,P<0.001)。放置LNg20时发生5例子宫穿孔(其中3例发生于
TCu380Ag is a copper-containing IUD, LNg20 is an IUD that releases 18 μg of levonuclease daily. In this paper, the author reports 2,225 women in seven clinical centers in the United States, Brazil, Chile, Egypt, Singapore and the Dominican Republic who used the 25-month randomized comparative study of the two IUDs described above. The subjects were 18-38-year-old women who requested IUD. According to the randomized table, 1,124 LNg20 patients and 1,120 patients with TCu380Ag patients were single-blind, and women did not know the type of IUD they placed. The results showed that LNg20 group (14.7%) was significantly higher than TCu380Ag group (3%), and the incidence of moderate or severe pain when placed in LNg20 group (18.8%) was significantly higher than that of TCu380Ag group (10.8%, P <0.001). Five cases of uterine perforation occurred while LNg20 was placed (three of them occurred