论文部分内容阅读
本文应用脑益嗪治疗５２例失代偿期肝硬化患者，并随机以４９例对照，经过２个月治疗后复查，结果脑益嗪组的肝功能改善明显优于对照组（Ｐ＜０．０１）。１年后随访，脑益嗪组５２例存活４９例，存活者肝功能由ＣｈｉｌｄＣ级上升为Ｂ级，腹水消失、营养状况明显改善。而对照组４９例只有２０例存活，存活者肝功能仍为ＣｈｉｌｄＣ级，腹水暂时消退只有５例，营养状况无１例改善（Ｐ＜０．０５）。可见脑益嗪的近远期疗效是显著的。其疗效机理与脑益嗪阻滞Ｃａ２＋由细胞外流向细胞内，保护了肝细胞，降低了门脉压力，改善了肝脏的循环有关。
In this paper, 52 patients with decompensated cirrhosis were treated with brain-yzine and randomly divided into 49 controls. After 2 months of treatment, the results showed that the improvement of hepatic function was significantly better in the brain-derived group than in the control group (P <0. 01). After one year follow-up, 52 patients survived in the brain of Yisuzarin group, and the liver function of survivors went from ChildC level to B level. The ascites disappeared and the nutritional status was significantly improved. The control group, 49 cases of only 20 cases of survival, survivors liver function is still ChildC grade, ascites temporarily subsided only 5 cases, no improvement in nutritional status (P <0.05). Can be seen near and far brain curative effect is significant. The mechanism of action and brain Yizhi block Ca2 + from the extracellular flow to the cells, protecting the liver cells, reducing portal pressure, improve the liver’s circulation.