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目的 观察重组干扰素 a Ib(滴宁滴眼液 )滴眼对翼状胬肉切除羊膜移植术后预防复发的效果。方法 对1 1 0例翼状胬肉切除羊膜移植术后病人 ,随机分成两组 ,治疗组 5 5例 ,用重组干扰素 a Ib(滴宁滴眼液 )滴眼治疗 ,对照组5 5例 ,应用氟美童 (氟甲松龙 )滴眼液滴眼治疗 ,并进行统计分析。结果 术后经过 6～ 1 4个月 ,平均 1 0个月随访 ,治疗组无 1例复发 ;对照组复发 4例 ,复发率为 7.3 %。结论 重组干扰素 a Ib滴眼液能很好地抑制翼状胬肉成纤维细胞的增殖及新生血管生长 ,是翼状胬肉切除羊膜移植术后预防复发的理想辅助药
Objective To observe the effect of recombinant interferon-alpha (Ib) eye drops on the prevention of recurrence after pterygium excision amniotic membrane transplantation. Methods One hundred and ten cases of pterygium excised amniotic membrane transplantation were randomly divided into two groups. In the treatment group, 55 cases were treated with recombinant interferon-alpha Ib (Eye drops), while in the control group, 55 cases were treated with amniotic membrane transplantation. Fluoromethodone (Flumethasone) eye drops eye drops treatment, and statistical analysis. Results After 6 ~ 14 months postoperatively, with an average of 10 months follow-up, none of the patients in the treatment group relapsed. In the control group, 4 patients relapsed and the recurrence rate was 7.3%. Conclusion The recombinant interferon-α Ib eye drops can effectively inhibit the proliferation and angiogenesis of pterygium fibroblasts and is an ideal adjuvant for preventing recurrence of pterygium excision amniotic membrane transplantation